Kodesh is more stringent than terumah in that utensils may be immersed inside other utensils for use with terumah but not for use with kodesh. The exterior, the interior and the handle are considered separate for terumah (so that they may become ritually impure independently) but this is not the case for kodesh. One who carries something impure (from “treading” - midras) may carry terumah at the same time but not kodesh. The garments of those who eat terumah are considered ritually impure for those who eat kodesh. Kodesh is not handled in the same manner as terumah, because for kodesh one must untie a knot in a garment, dry it, immerse it and then re-tie it, while for terumah one may simply tie the garment and immerse it.
Vessels that were completed in a state of ritual purity must be immersed in a mikvah for use with kodesh but not for use with terumah. A vessel unites its contents for kodesh but not for terumah. Even fourth-degree ritual impurity invalidates kodesh but ritual impurity only invalidates terumah up to the third degree. For terumah, if one hand becomes ritually unclean, the person’s other hand is still ritually clean; for kodesh, he must immerse both hands. This is because one hand renders the other ritually unclean for kodesh but not for terumah.